Turn the oven on to 325°F
Grind fennel seeds and red pepper flakes in a spice grinder or with a mortar & pestle until very fine. Toss spice mixture with the orange zest and 2 tsp of the salt. Rub the turkey breast with the salt mixture, then transfer it to baking dish, cover and refrigerate while you prepare the stuffing.
Toast the panko in a 12-inch ovenproof skillet over medium heat, stirring with a rubber spatula until golden brown. Remove to a bowl and set aside.
To the same pan, over medium-high heat, add 1 Tbsp of olive oil with the pancetta. Cook stirring often, until brown and crisp, 5–8 minutes. Transfer the pancetta to a plate, reserving the oil in the pan. Add the garlic and cook until fragrant then add the apples, shallots, fennel, rosemary, sage, and thyme and cook until just tender about 5 minutes. Add to the bowl with the panko, add the pancetta and toss to combine. Add chopped parsley and season mixture well with salt and pepper.
Unfold the butterflied turkey breast and spread the stuffing evenly over the surface of the breast. Roll up turkey breast like a jelly roll to form a log, position seam side down and tuck skin under at each end. Loop a length of string around outside edge and tie closed. Starting at center, tie with kitchen twine at even intervals (apply some pressure with string so turkey holds a nice round shape, but don’t tie too tightly or it will bulge when cooked).